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title: Sandwalk

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B tags

Larry Moran is a Professor in the Department of Biochemistry at the University of Toronto. You can contact him by looking up his email address on the University of Toronto website.

The Sandwalk is the path behind the home of Charles Darwin where he used to walk every day, thinking about science. You can see the path in the woods in the upper left-hand corner of this image.

Some readers of this blog may be under the impression that my personal opinions represent the official position of Canada, the Province of Ontario, the City of Toronto, the University of Toronto, the Faculty of Medicine, or the Department of Biochemistry. All of these institutions, plus every single one of my colleagues, students, friends, and relatives, want you to know that I do not speak for them. You should also know that they don't speak for me.

The old argument of design in nature, as given by Paley, which formerlyseemed to me to be so conclusive, fails, now that the law of natural selection has been discovered. We can no longer argue that, for instance, the beautiful hinge of a bivalve shell must have been made by an intelligent being, like the hinge of a door by man. There seems to be no more design in the variability of organic beings and in the action of natural selection, than in the course which the wind blows.

Although I am fully convinced of the truth of the views given in this volume, I by no means expect to convince experienced naturalists whose minds are stocked with a multitude of facts all viewed, during a long course of years, from a point of view directly opposite to mine. It is so easy to hide our ignorance under such expressions as "plan of creation," "unity of design," etc., and to think that we give an explanation when we only restate a fact. Any one whose disposition leads him to attach more weight to unexplained difficulties than to the explanation of a certain number of facts will certainly reject the theory.

Charles Darwin (1859)Science reveals where religion conceals. Where religion purports to explain, it actually resorts to tautology. To assert that "God did it" is no more than an admission of ignorance dressed deceitfully as an explanation...

My own view is that conclusions about the evolution of human behavior should be based on research at least as rigorous as that used in studying nonhuman animals. And if you read the animal behavior journals, you'll see that this requirement sets the bar pretty high, so that many assertions about evolutionary psychology sink without a trace.

It is naïve to think that if a species' environment changes the species must adapt or else become extinct.... Just as a changed environment need not set in motion selection for new adaptations, new adaptations may evolve in an unchanging environment if new mutations arise that are superior to any pre-existing variations

One of the most frightening things in the Western world, and in this country in particular, is the number of people who believe in things that are scientifically false. If someone tells me that the earth is less than 10,000 years old, in my opinion he should see a psychiatrist.

There will be no difficulty in computers being adapted to biology. There will be luddites. But they will be buried.

An atheist before Darwin could have said, following Hume: 'I have no explanation for complex biological design. All I know is that God isn't a good explanation, so we must wait and hope that somebody comes up with a better one.' I can't help feeling that such a position, though logically sound, would have left one feeling pretty unsatisfied, and that although atheism might have been logically tenable before Darwin, Darwin made it possible to be an intellectually fulfilled atheist

Another curious aspect of the theory of evolution is that everybody thinks he understand it. I mean philosophers, social scientists, and so on. While in fact very few people understand it, actually as it stands, even as it stood when Darwin expressed it, and even less as we now may be able to understand it in biology.

The false view of evolution as a process of global optimizing has been applied literally by engineers who, taken in by a mistaken metaphor, have attempted to find globally optimal solutions to design problems by writing programs that model evolution by natural selection.

Principles of Biochemistry

Principles of Biocemistry: International Edition

Moran, L.A.,Scrimgeour, K.G. et al.

U tags

standard

actual

not

is

logically

I tags

bis

Although the cleavage of fructose-1,6-bisphosphate is frequently unfavorable (ΔG'° = +23.8 kJ/mol), the reaction proceeds because the products are rapidly removed.

Evolution News & Views

Evolution News & Views

Sandwalk

Why Evolution Is True

Panda;s Thumb

Thoughts from Kansas

This is part 12 of my review of The Myth of Junk DNA

Genomes & Junk DNA

Gene Expression

For that matter, people who put their genotypes in the public domain are partially exposing their whole families. Do they have to go ask for permission? Obviously I don’t think so. I didn’t ask my siblings or my parents.

Evolutionary Genomics Blog

I cannot help but worry about the issues regarding disclosure of genetic information. As long as the public has faith in the geneticists ability to predict phenotypes, the implications of disclosing genetic information are enormous. When my brother in a few years are being considered for a position as CEO for a major company, I am sure he wouldn’t appreciate if I disclose that I carry a mutation that disposes me to early onset of Alzheimer’s disease. He might after all then also carry the mutation with 50% chance. Even if we wouldn’t want to ban me from disclosing information about myself, the nice thing for me to do would nonetheless be to talk with my brother before making the disclosure.

Going back to Nielsen’s post he contends that it would be the “nice thing” for him to do to consult his sibling if he was going to disclose genetic information which might have broader impact upon him (in this case, the potential presence of a gene predisposing someone to Alzheimer’s). I think that’s key: I don’t have much of an issue with scientists who follow their conscience, and try to be decent human beings. Scientists are people too; not just analytic computation machines. The problem is when a legal framework emerges which regulates what science is, and isn’t, done. Obviously at the boundary I totally agree with the idea that science has some ethical constraints. We wouldn’t want a thousand Mengele’s to bloom. But I think the legal threshold should be set rather high. If governmental bodies begin to regulate the bounds of scientific inquiry at a fine-grained level that’s a pretty strong incentive for aspiring Leon Kass’ to take over such agencies.

Your publicly available DNA sequence data, trait data and other information will include certain information that applies to your family members. Some people may draw conclusions from your publicly available information, including speculating about what such information might reveal about you and your family members. As a result, the PGP cannot predict all of the risks, or the severity of the risks, that the public availability of this information may pose to you and your relatives. You are strongly encouraged to discuss this study and its potential risks, including the fact that not all of the risks are known, with your immediate family members.

The Botany Photo of the Day

Cooksonia pertoni

Cooksonia

This month's Carnival of Evolution

EvoEcoLab

The great tragedy of science—the slaying of a beautiful hypothesis by an ugly fact.

Uncertain Principles

So, if you had money to bet on it, bet that this result is wrong. But these guys aren't complete chumps, and if something is wrong with their experiment, it's something pretty subtle, because they've checked all the obvious problem areas carefully.

Some readers of this blog may be under the impression that my personal opinions represent the official position of Canada, the Province of Ontario, the City of Toronto, the University of Toronto, the Faculty of Medicine, or the Department of Biochemistry. All of these institutions, plus every single one of my colleagues, students, friends, and relatives, want you to know that I do not speak for them. You should also know that they don't speak for me.

The old argument of design in nature, as given by Paley, which formerlyseemed to me to be so conclusive, fails, now that the law of natural selection has been discovered. We can no longer argue that, for instance, the beautiful hinge of a bivalve shell must have been made by an intelligent being, like the hinge of a door by man. There seems to be no more design in the variability of organic beings and in the action of natural selection, than in the course which the wind blows.

Although I am fully convinced of the truth of the views given in this volume, I by no means expect to convince experienced naturalists whose minds are stocked with a multitude of facts all viewed, during a long course of years, from a point of view directly opposite to mine. It is so easy to hide our ignorance under such expressions as "plan of creation," "unity of design," etc., and to think that we give an explanation when we only restate a fact. Any one whose disposition leads him to attach more weight to unexplained difficulties than to the explanation of a certain number of facts will certainly reject the theory.

Science reveals where religion conceals. Where religion purports to explain, it actually resorts to tautology. To assert that "God did it" is no more than an admission of ignorance dressed deceitfully as an explanation...

My own view is that conclusions about the evolution of human behavior should be based on research at least as rigorous as that used in studying nonhuman animals. And if you read the animal behavior journals, you'll see that this requirement sets the bar pretty high, so that many assertions about evolutionary psychology sink without a trace.

TIBS

It is naïve to think that if a species' environment changes the species must adapt or else become extinct.... Just as a changed environment need not set in motion selection for new adaptations, new adaptations may evolve in an unchanging environment if new mutations arise that are superior to any pre-existing variations

One of the most frightening things in the Western world, and in this country in particular, is the number of people who believe in things that are scientifically false. If someone tells me that the earth is less than 10,000 years old, in my opinion he should see a psychiatrist.

There will be no difficulty in computers being adapted to biology. There will be luddites. But they will be buried.

An atheist before Darwin could have said, following Hume: 'I have no explanation for complex biological design. All I know is that God isn't a good explanation, so we must wait and hope that somebody comes up with a better one.' I can't help feeling that such a position, though logically sound, would have left one feeling pretty unsatisfied, and that although atheism might have been logically tenable before Darwin, Darwin made it possible to be an intellectually fulfilled atheist

Another curious aspect of the theory of evolution is that everybody thinks he understand it. I mean philosophers, social scientists, and so on. While in fact very few people understand it, actually as it stands, even as it stood when Darwin expressed it, and even less as we now may be able to understand it in biology.

The false view of evolution as a process of global optimizing has been applied literally by engineers who, taken in by a mistaken metaphor, have attempted to find globally optimal solutions to design problems by writing programs that model evolution by natural selection.

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Laurence A. Moran
Sandwalk
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Monday, October 17, 2011

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Laurence A. Moran

Sandwalk

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How much of the human genome is junk?

What's the best way to describe a graduate student?

What should scientific organizations like AAAS and NAS say about religion?

You are waiting in line at the post office. It will take 30 minutes to reach the counter. For $3 someone will move you to the front of the line. Would you ...

Which brower do you use?

How would you describe your political point of view?

Whose view of evolution is closest to your own?

How would you describe yourself?

How much of our genome could be deleted without having any significant effect on our species?

Look at the diagram on Monday's Molecule #62, posted on Monday February 11, 2008. Do you know what's going on?

H3

Monday, October 17, 2011

Sunday, October 16, 2011

Friday, October 14, 2011

Wednesday, October 12, 2011

Tuesday, October 11, 2011

Saturday, October 08, 2011

Friday, October 07, 2011

Laurence A. Moran

Sandwalk

Recent Comments

Principles of Biochemistry 5th edition

Recent Posts

Themes

Subscribe to Sandwalk

Rationalism

Superstition

Slideshow

Followers

Quotations

Essays and Articles

Sandwalk Archive

Labels

Subscribe To Sandwalk

Principles of Biochemistry 4th edition

Principles of Biochemistry: International Edition

Biochemistry 2nd ed. (1994)

Search Sandwalk

Moon Phases

Technorati

How much of the human genome is junk?

What's the best way to describe a graduate student?

What should scientific organizations like AAAS and NAS say about religion?

You are waiting in line at the post office. It will take 30 minutes to reach the counter. For $3 someone will move you to the front of the line. Would you ...

Which brower do you use?

How would you describe your political point of view?

Whose view of evolution is closest to your own?

How would you describe yourself?

How much of our genome could be deleted without having any significant effect on our species?

Look at the diagram on Monday's Molecule #62, posted on Monday February 11, 2008. Do you know what's going on?

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Have Humans Stopped Evolving?
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Kevin O'Leary
Dragon's Den
NUPGE / OPSEU file complaint with CBC Ombudsman over offensive anti-union comments by Kevin O'Leary
CBC ombudsman says O'Leary's 'nutbar' remark violated journalistic standards
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How Do We Know Intelligent Design Is a Scientific "Theory"?
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A Reason to Doubt the Real, Rather than Pretended, Confidence of Darwin Advocates
conservababes
1 comments
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All your genes belong to the tribal council!
Do the genes belong to the tribal council?
Decency not by law alone
Personal Genomes Project
The Spittoon
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Cooksonia pertoni
The Carnival of Evolution
the mermaid's tale
Carnival of Evolution
Carnival of Evolution
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Rights and freedoms and religion
national anthem
constitution
Measurement of the neutrino velocity with the OPERA detector in the CNGS beam
Faster Than a Speeding Photon: "Measurement of the neutrino velocity with the OPERA detector in the CNGS beam"
No Cause to Dispute Einstein
Can Neutrinos Kill Their Own Grandfathers?
Adventures in Ethics and Science
Bad Astronomy
Bayblab
beer with chocolate
Botany Photo of the Day
Canadian Atheist
Catalogue of Organisms
Cosmic Variance
Dr. Joan Buswell's Chimpanzee Refuge
Effect Measure
evolgen
Evolving Thoughts
Friendly Atheist
Gene Expression
Genomicron
Greg Laden's Blog
Helmintholog
john hawks weblog
Laelaps
Leslie Jane Moran
Memoirs of a Skepchick
Mike's Weekly Skeptic Rant
Musings of the Mad Biologist
Pharyngula
Recursivity
Respectful Insolence
RichardDawkins.net
Sex, Genes & Evolution
The Daily Transcript
The Lippard Blog
The Loom
The Loom
The Panda's Thumb
The Unexamined Life
Thoughts in a Haystack
Why Evolution Is True
Post Darwinist
Evolution News & Views
Uncommon Descent
Charles Darwin (c1880)
Charles Darwin (1859)
Peter Atkins
Theistic Evolution: The Fallacy of the Middle Ground
Evolution by Accident
Evolution and Abiogenesis
Macroevolution
Random Genetic Drift
The Modern Synthesis of Genetics and Evolution
Evolution Is a Fact and a Theory
Michael Behe's Criticism of Biochemistry Textbooks
The HSP70 Sequence Database
Stephen Jay Gould (1982)
Stephen Jay Gould (2002) p.1339
Stephen Jay Gould (1977)
Stephen Jay Gould (1980)
Stephen Jay Gould (1983) p.335
Stephen Jay Gould (1999) p.84
lunar phase
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